This interaction plays a key role in maintaining the survival and drug resistance of MM tumor cells, mediated mostly by direct contact (adhesion) or secretion of a plethora of cytokines and growth factors by BMSCs or MM cells, including IL-6, VGEF, IGF-1, HGF, IL-3 and RANK [3, 4]. This evidence concerns the gene TNFRSF11A and Miyoshi myopathy.