Additionally, TQ significantly downregulated genes associated with poor GBM prognosis, including PCSK5, KCNC1, MXRA5, SEMA3C, MFAP2, MTERF2, KDM2B, FOXP2 [73–79], indicating TQ’s potential in targeting key molecular pathways in GBM. Here, PCSK5 is linked to glioblastoma.