LRRK2 and Parkinson disease: Pathogenic activation of LRRK2 exerts downstream effects including lysosomal stress that confers cross-talk with additional PD-linked proteins including VPS13C and GBA1 (14, 61, 62), and this is associated with loss of primary cilia in selective cell types in the striatum of LRRK2 mutant mice (11, 56).