α-TTP mRNA is detected predominantly in the Purkinje layer of the cerebellar cortex and, in AVED patients, loss of α-TTP causes severe damage to Purkinje cells in the brain (Larnaout et al. 1997; Hosomi et al. 1998; Ulatowski et al. 2014). The gene discussed is TTPA; the disease is familial isolated deficiency of vitamin E.