Given that a deleterious role for m6A/METTL3 deregulation in ccRCC biology has been established, and that m6A may be targeted in part by SETD2 mediated H3K36me3, which is frequently lost in ccRCC and linked to poor outcome, we sought to investigate the interplay between SETD2 and m6A patterning/localization in the transcriptome of SETD2 deficient ccRCC. Here, SETD2 is linked to nonpapillary renal cell carcinoma.