Indeed, these targets included several loci such as HM13, LY96, DNMT3B, TNFRSF12A, SLC29A3, SERPINH1 and CHPF that were upregulated and m6A hypermethylated in the 786-O isogenic model, which were also significantly upregulated in primary ccRCC and associated with poor RCC-specific survival [43–45] (Figure 2c, Supplemental Figure S3C). This evidence concerns the gene DNMT3B and nonpapillary renal cell carcinoma.