To understand the interplay between SETD2 status and m6A localization in RCC relevant models, we made use of previously generated isogenic SETD2 KOs in the ccRCC cell line 786-O (referred to as SETD2KO–1 and SETD2KO–2) and the surrogate normal immortalized renal proximal tubule cell line RPTEC (SETD2 KOs also referred to as SETD2KO–1 and SETD2KO–2). The gene discussed is SETD2; the disease is renal cell carcinoma.