The m6A writer METTL3, which forms a crucial component of the core methyltransferase complex [22], is significantly overexpressed in ccRCC compared to normal kidney and higher expression correlates with reduced ccRCC survival [40,41], suggesting a role for m6A in ccRCC progression (Supplemental Figures S1A,B). This evidence concerns the gene METTL3 and nonpapillary renal cell carcinoma.