After observing the enrichment of m6A hypermethylation and upregulation of genes consistent with known metabolic shifts in ccRCC, and given the functional importance of m6A in mRNA metabolism, we assessed the impact of depleting m6A writer METTL3 on gene expression patterns in SETD2 deficient cells. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.