It has been reported that the reduction of p62 gene expression can alleviate autophagy in Alzheimer's disease,[70] and the mononuclear cell motility inhibitory factor can increase cell survival rate and reduce cell apoptosis by inhibiting the expression of caspase 3 in myocardial cells.[66] Consistent with our results, administration of Asp to oxidative stress enterocytes effectively reversed the expression of RIP1, p62, caspase3, and NF‐κBp65 and the levels of inflammatory factors. Here, CASP3 is linked to early-onset autosomal dominant Alzheimer disease.