These include cell lines derived from advanced thyroid cancers in TPO-Cre/LSL-KrasG12D/Ptenf/f (84), TPO-CreERT2/BrafCA/Ptenf/f (85), TPO-CreERT2/BrafCA/Trp53f/f (85), TPO-Cre/FR-HrasG12V/Ptenf/f (86) and TPO-Cre/LSL-Braf/Ptenf/+ (87) mice, which have been discussed in previously published reviews (12, 13). The gene discussed is BRAF; the disease is thyroid cancer.