TPO and neoplasm: Immunohistochemistry staining for F4/80 and CD206 by Yan et al. (35) in ATCs from TPO-Cre/LSL-Braf/p53−/− mice, along with immune deconvolution of RNAseq data from ATCs in TPO-CreERT2/BrafCA/p53f/f mice (27), revealed high tumor infiltration of M2-like macrophages, similar to what has been observed in human ATCs (36, 37, 38).