Recently, using a targeted deletion strategy, we generated a PC‐specific Nfat5‐KO mouse model using an Aqp2‐driven Cre‐deleter (Aqp2Cre+/−Nfat5fl/fl) that results in a diabetes insipidus‐like phenotype.17 This evidence concerns the gene NFAT5 and diabetes insipidus.