Though found in approximately 20% of patients with CD, we consider that if present at baseline, leukocytosis could be valuable in preoperative assessments alongside other factors like cavernous sinus invasion, tumor size, preoperative ACTH levels, and disease duration, all of which have been linked to higher chance of immediate remission [3, 21]. The gene discussed is POMC; the disease is Increased total leukocyte count.