Unspecific Bone Uptakes (UBUs) are incidental findings frequently observed in prostate cancer (PCa) patients undergoing Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (PSMA PET/CT), particularly with [18F]PSMA-1007 [1–6]. The gene discussed is FOLH1; the disease is posterior cortical atrophy.