In DLBCL cells with APOC1 knockdown, the phosphorylation levels of key pathway proteins—phospho-Ser249-PI3K/PI3K, phospho-T308-Akt/Akt, and phospho-S2448-mTOR/mTOR—were significantly reduced compared to the sh-NC group. The gene discussed is APOC1; the disease is diffuse large B-cell lymphoma.