This aligns with evidence that high APOC1 expression enhances the secretion of cytokines, such as EGF, PDGF, VEGFA, IL-1, IL-8, TNF-α, MMP-9, MMP-2, and NO, which collectively drive tumor cell proliferation, invasion, and angiogenesis [51]. This evidence concerns the gene CXCL8 and neoplasm.