TG and hypothyroidism: Furthermore, earlier data reported that castration reduced the ratio of smooth muscle to collagen and increased connective tissue in the urinary bladder, whereas TRT normalized the amount of smooth muscle.9,21 According to the results, an increased amount of smooth muscle is more linked to T levels than thyroid hormone levels; thus, treatment with levothyroxine may not guarantee the amendment of hypothyroidism-induced bladder dysfunction.