The present study using speckle tracking analysis adds new information on the differences in cardiac functional characteristics between AL‐CM and TTR‐CM; (1) the apical sparing phenomenon was more remarkable in TTR‐CM, when compared to AL‐CM; (2) there was a difference in the relationship between RASI and LVMI, where RASI was getting higher as myocardial hypertrophy worsened in AL‐CM while no association was found in TTR‐CM; and (3) RASI proved effective for discriminating between AL‐CM and TTR‐CM, with a cutoff value of 1.0 for the RASI. This evidence concerns the gene TTR and cardiac hypertrophy.