These results are in line with previous reports showing that nuclei in lamin A/C‐knockout cells[29] or in cells with LMNA mutations that lead to muscular dystrophy are more deformable than those in normal cells.[30] Thus, because they mechanically challenge nuclei, microgrooves can reveal functional abnormalities that can be automatically detected and quantified, paving the way for potential diagnostic applications. The gene discussed is LMNA; the disease is muscular dystrophy.