TP53 and neoplasm: Mutations in TP53, a crucial tumour suppressor mutated in a wide variety of cancer types, were observed in CHM and PHM using highly sensitive pyrosequencing, but not with Sanger sequencing (Chen et al., 1994; Cheung et al., 1994; Shi et al., 1996), indicating that these mutations occur only in a subpopulation of molar cells and are thus unlikely to be crucial in tumourigenesis (Chan et al., 2018).