MTOR and fatty liver disease: It has been shown that mTOR expression levels are upregulated after high-fat/calorie diet plus high fructose/glucose in drinking water (HFCD-HF/G, or HFCFG) feeding [6] and that administration of inhibitors of mTOR inhibits hepatic steatosis and influences the pathology of metabolic dysfunction-associated fatty liver disease (MAFLD) by modulating the inflammatory response [7, 8].