On the other hand, CHRM4 encodes the muscarinic acetylcholine receptor M4, which has been proposed as a therapeutic target for schizophrenia (Gibbons and Dean, 2016; Gould et al., 2018), Therefore, conservation of rhythms in CHRM4 across species may be important for successful translation of these drugs into humans. Here, CHRM4 is linked to schizophrenia.