To understand whether FSP27 deficiency affects the development of thoracic aortic aneurysms and dissection (TAAD), we analyzed echocardiography and found that the incidence of TAAD was comparable in WT (1 in 9) and Fsp27−/− mice (1 in 7) fed with an HFD and infused with Ang II (Supplementary Fig. S5a). The gene discussed is AGT; the disease is Rare disease with thoracic aortic aneurysm and aortic dissection.