FGF21 and postmenopausal osteoporosis: Among them, microRNA-17-5p is a novel endothelial cell modulator and controls vascular reendothelialization and neointimal lesion formation, whereas MiR-26b-5p regulates the preadipocyte differentiation by targeting FGF21 in goats, and MiR-16-5p regulates postmenopausal osteoporosis by directly targeting VEGFA (Liu et al., 2023; Ma et al., 2021; Yu et al., 2020).