The 12 shared DEGs including HSPB1, VIM, MVD, TUBB4A, AACS, ANXA6, DIRAS2, RPH3A, CEND1, KALM, THOP1, AREL1, previous studies have shown that these DEGs are highly correlated with nHIBD and AD. This evidence concerns the gene CEND1 and Alzheimer disease.