TLR4 and Alzheimer disease: Interestingly, both nHIBD and AD have been demonstrated to be associated with TLR4 and Ferroptosis, and AQP4 level was reported to be decreased in both nHIBD and AD (Chandra et al., 2021; Ruganzu et al., 2022; Wang et al., 2023; Yu et al., 2012; Zhu et al., 2021).