The 12 shared DEGs including HSPB1, VIM, MVD, TUBB4A, AACS, ANXA6, DIRAS2, RPH3A, CEND1, KALM, THOP1, AREL1, previous studies have shown that these DEGs are highly correlated with nHIBD and AD. The gene discussed is HSPB1; the disease is Alzheimer disease.