B. vulgatus disrupts insulin sensitivity and ovarian function, resulting in a decreased level of TUDCA and infiltration of RORγT+ IL-22+ ILC3s in siLP. GDCA promotes the production of IL-22 as well as improved IR and ovarian dysfunction in PCOS-like mice by activating the GATA3 signaling pathway [6]. The gene discussed is GNAT3; the disease is polycystic ovary syndrome.