TREM2 and metabolic dysfunction-associated steatotic liver disease: TREM2 was reported to maintain macrophage-hepatocyte metabolic coordination in NAFLD and prolonged hyper nutrition leads to the production of proinflammatory cytokines, which induces TREM2 shedding through A disintegrin and metallopeptidase domain 17 (ADAM17)-dependent proteolytic cleavage and thus exacerbates the progression of NASH [104, 105].