IL17A and obesity due to melanocortin 4 receptor deficiency: Increase the abundance of Akkermansia muciniphila and control obesity and metabolic disorders via secretion of IL-17 [169]. HFD eliminates the Th17 cell-inducing SFB and disrupts the intestinal immune-mediated by Th17 cells, which protect mice from DIO by regulating epithelial lipid absorption [13].