CLSTN3B expression in SAT and VAT samples was inversely correlated with several metabolic characteristics of obesity and adipose tissue, including body fat%, waist-to-hip ratio, circulating levels of triglyceride (TG), adipokine leptin, and inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP)], and it was positively associated with circulating concentrations of high-density lipoprotein cholesterol (HDL-C) and adiponectin. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.