A constitutive suppression of miR-145 by ASO exacerbated monocyte infiltration in the liver, while systematic overexpression of miR-145 by lentivirus alleviated obesity, inflammation, and insulin resistance in db/db mice, and moderated atherosclerosis in ApoE−/− mice [31]. This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.