NT5E and Autoimmunity: Dynamic CD73 alterations have also been observed in other pathophysiological conditions (e.g., autoimmunity, infections, cardiovascular and atherosclerotic diseases), as well as in response to hormonal changes, with unknown consequences for occurrence of irAE in combined radio-immunotherapies (Deaglio and Robson, 2011; Nikolova et al., 2011; Bönner et al., 2012; Antonioli et al., 2013; Lee et al., 2021; Ndzie Noah et al., 2023).