NT5E and neoplasm: Adenosine generated by CD73 mainly inhibits NK cell activities via A2A (Raskovalova et al., 2006; Wang and Matosevic, 2018), thus leading to impaired maturation, activation, and cytotoxic potential of NK cells (Raskovalova et al., 2006; Beavis et al., 2013; Hatfield et al., 2015; Young et al., 2016; Chambers et al., 2018); in addition, NK cells in the tumor microenvironment undergo transcriptional reprogramming and upregulate IL-10 production (Neo et al., 2020).