HMGA2 and pancreatic neoplasm: Munshi HG et al. first found that type I collagen increases ERK1/2 phosphorylation and high mobility group A2 (HMGA2) expression through MT1-MMP, and that HMGA2 is highly expressed in high-grade pancreatic tumors with lymph node metastasis, attenuating gemcitabine-induced checkpoint blockade (Dangi-Garimella et al., 2011; Dangi-Garimella et al., 2013).