The ability of telocytes to influence macrophage polarization via the HGF-Met pathway from an inflammatory (M1) state toward a tissue-remodeling phenotype (M1/M2) in a preclinical model of periodontitis (Zhao et al., 2022) hints at the potential of telocyte-macrophage interactions in IBD and its associated fibrosis. This evidence concerns the gene HGF and inflammatory bowel disease.