Interestingly, in the context of chronic colonic inflammation, Jasso et al. (2022) previously showed (scRNAseq analysis) that in chronic DSS colitis, several fibroblast subsets expressed the IL-6 family cytokine IL-11 and the receptor subunits IL-11ra and IL-6th (Jasso et al., 2022). The gene discussed is IL11; the disease is colitis.