In CD4+ TCs, the percentage of naïve TCs and the expression of the related markers (CD45RA and LEF1) decreased, while the percentages of Tem and Tex and the expression of the corresponding markers (CD45RO and CD279, respectively) increased in VKH disease (Fig. 3B–3D). The gene discussed is PDCD1; the disease is Vogt-Koyanagi-Harada disease.