OXGR1 and male infertility: In a recent study published in Life Metabolism, Xu et al. report that the α-ketoglutaric acid (AKG)/2-oxoglutarate receptor 1 (OXGR1) signaling plays an important role in the regulation of sperm maturation by maintaining epididymal fluid acid–base balance in epididymal smooth muscle cells, suggesting that AKG may provide a new chance for nutritional intervention of some male infertility.