Moreover, consistent with the idea that cellular senescence is being regarded as an anti-cancer mechanism and the expression levels of many genes are opposite in senescence and cancer [5, 6], we found that PTBP1 was up-regulated in most cancer types (Fig. S6A), and its expression level is negatively correlated with patients’ survival rates and positively correlated with the expression levels of such cell proliferation marker genes (such as CDK1, MKI67, and LMNB1, etc.)in all combined cancer types in TCGA (Fig. S6B–E). The gene discussed is MKI67; the disease is cancer.