The combination of DU102 (5 mg/kg) and anti-PD-1 antibody showed significantly enhanced anti-­tumor activity compared to that of either DU102 or anti-PD-1 antibody alone (Fig. 7a and b, Supplementary Fig. S7b and c), without affecting body weights and spleen weights of the mice (Fig. 7c, Supplementary Fig. S7d). The gene discussed is PDCD1; the disease is neoplasm.