There is a trend of the same pattern of increased total Tau levels in AD lines compared to control lines is evident at 12 weeks (Fig. 4c) however, no significant differences are observed at this time point between the different cell lines, although there seems to be a significant increase in the AD lines (combined) when compared to the control lines (combined) (**p = 0.0015) (Fig. 4d). This evidence concerns the gene MAPT and Alzheimer disease.