INS and type 2 diabetes mellitus: Patients with T2DM and DR were more likely to use insulin (OR=3.63, 95% CI 1.89-7.00), have a longer duration of diabetes (OR=1.04 per year, 95% CI 1.02-1.07), and exhibit higher systolic blood pressure (OR=1.01 per mmHg, 95% CI 1.00-1.02) [37].