ACE and Granuloma: The workup includes imaging, laboratory evaluation with serology, microbiological testing, and biomarker analysis, such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), angiotensin-converting enzyme (ACE), and soluble IL-2 receptor (sIL-2R), and a biopsy (e.g., endobronchial ultrasound {EBUS}-guided transbronchial needle aspiration {TBNA}) to confirm non-caseating granulomas and exclude other etiologies.