50-year-old or older patients with type 2 diabetes. HbA1c of <9.5% with or without a stable insulin regimen. Diabetic patients stable on oral antihyperglycemic drugs. Patients with at least two CVS risk factors or a history of previous CVS events. Patients with BMI > 23 kg/m2. This evidence concerns the gene INS and type 2 diabetes mellitus.