However, with obesity, we observed increased accessibility of genes involved in cell cycle regulation (ATM, CDKN1C, BCL2L11), autophagy (HSPA8, IRF8, PEX5), and protein catabolism (CDC34, CTSB, UBB) (Figure 6F). The gene discussed is CTSB; the disease is obesity due to melanocortin 4 receptor deficiency.