However, with obesity, we observed increased accessibility of genes involved in cell cycle regulation (ATM, CDKN1C, BCL2L11), autophagy (HSPA8, IRF8, PEX5), and protein catabolism (CDC34, CTSB, UBB) (Figure 6F). Here, HSPA8 is linked to obesity due to melanocortin 4 receptor deficiency.