GO analysis showed that the upregulated genes in the keloid KLF2+ Tregs were associated with the platelet-derived growth factor receptor signaling pathway and the regulation of B cell activation, and the upregulated genes in the keloid LAIR2+ Tregs were associated with the toll-like receptor 2 signaling pathway (Supplementary Figure S4D). The gene discussed is TLR2; the disease is keloid.