In the KEGG pathway enrichment analysis, NK cells were found to exhibit analogous regulatory patterns to B cells and CD8 T cells in biological processes such as natural killer cell-mediated cytotoxicity, primary immunodeficiency, ribosomal signaling, antigen preparation and presentation processes, as well as T cell receptor-mediated signaling (Supplementary Figures S3, S4). The gene discussed is CD8A; the disease is inborn error of immunity.