Based on the results of differential expression analysis, we further analyzed the correlations between the five co-expressed genes and 22 immune cell subpopulations, and the results showed that all five co-expressed genes were correlated with some immune cells, especially PSRC1 and COLEC12. Specifically, we found that in the up-regulated cancer-enriched genes (CEGs), PSRC1 was positively correlated with T cells follicular helper and activated NK cells. The gene discussed is COLEC12; the disease is cancer.