Numerous signaling pathways are implicated in the regulation of apoptosis in NSCLC, including but not limited to STAT3, Wnt/β-catenin, NF-κB, PI3K/AKT, mTOR, MAPK/Slug, ROS, p53, and Nrf2. The gene discussed is NFE2L2; the disease is non-small cell lung carcinoma.