However, in addition to these shared cytokine changes in PV and AA, we also find dysregulation in other pathways and cytokines in PV - in particular, certain pro-inflammatory cytokines (IL-1α), chemokines (IL-8), and the Th2 pathway (IL-13) - that had not been analyzed in our AA studies. The gene discussed is IL1A; the disease is acquired polycythemia vera.