To mechanistically define the protective element of Tet2-adipocyte knockout in obesity, wild-type (WT) and adipocyte Tet2 deficient mice were fed a high-fat diet, however, Tet2-adipocyte knockout mice were given daily doses of leptin to create an artificial hyperleptinemic state analogous to WT mice. The gene discussed is TET2; the disease is obesity due to melanocortin 4 receptor deficiency.