We treated Huh7 cells with BD1 inhibitor (GSK778) or BD2 inhibitor (GDK046) and found that Huh7 cells were only sensitive to BD1 inhibitor but refractory to BD2 inhibitor (Supplementary Fig. S1f), suggesting that BD1 mediated the oncogenic functions of BET proteins in liver cancer. This evidence concerns the gene DEFB1 and liver cancer.