CXCL8 and cancer: Numerous studies have shown that levels of several inflammatory cytokines, including IL-6, IL-8, C-reactive protein (CRP) and TNFα increase with age, even in healthy individuals [35–37] This progressive tendency towards a pro-inflammatory phenotype with age was coined “inflammageing” [38] and plays a role in many age-related diseases, including cancer [35, 39, 40].