In a similar vein, the anti-invasive effects of endurance exercise against age-related invasiveness in breast cancer cells observed in the current study may not be solely attributable to the changes in inflammatory markers after individual exercise bouts completed by participants, but by their overall inflammatory status, which may well be mediated by other factors, such as levels of body fat resulting from exercise, or sex hormones [48–50]. Here, PLXNA3 is linked to breast carcinoma.