Using hepatocyte-specific CRISPRa screening and sLP-mCherry niche labeling system [78], Andreas Moor and colleagues identify that plexin B2 (Plxnb2) expressed by hepatocytes bound to class IV semaphorins (Sema4) on CRC surface, and promotes epithelialization of CRC and liver metastasis [79]. This evidence concerns the gene SEMA3F and colorectal carcinoma.