TARDBP and amyotrophic lateral sclerosis: These fibrillar aggregates include amyloid β (Aβ) fibrils and Tau-composed neurofibrillary tangles (NFT) in AD [20–22], α-synuclein (α-syn) fibrils in PD [23–25], and TDP-43 fibrils in FTLD and ALS [26–28].