Significantly, TMEM106B genetic variations have been found to not only influence the risk of developing FTLD, AD [4, 5, 10, 11], hippocampal sclerosis of aging [42, 43], and limbic-predominant age-related TDP-43 encephalopathy (LATE) [44, 45], but also associated with the progression of multiple NDs [6, 16]. Here, TMEM106B is linked to Alzheimer disease.