CGAS and neoplasm: Thirdly, while MRE11 lactylation promotes DNA damage repair and chemoresistance [6], MRE11 has recently been shown to activate cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING)-mediated signaling for tumor suppression through immunosurveillance, which requires MRE11’s DNA binding but not nuclease activity [8].