Research findings indicate that 1,25(OH)2D reduces lipid accumulation in cancer cells, emphasizing the possible role of lipid metabolism in Vit D-induced anti-cancer effects.86, 87, 88 Additionally, 1,25(OH)2D treatment inhibited de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells by suppressing the expression of the anaplerotic enzyme pyruvate carboxylase. The gene discussed is PC; the disease is cancer.