ACSL5 is localized to the mitochondria, and it converts free long-chain fatty acids with 16–18 carbons, such as oleic acid, linoleic acid, and palmitic acid, to fatty acyl-coenzyme A. ACSL5 participates in pro-apoptotic sensing and acts as a tumor suppressor in cancers [63]. Here, ACSL5 is linked to neoplasm.