Histology analysis confirmed that AAV-Igf2bp2-injected mice developed severe hepatic steatosis and inflammation, hepatocyte apoptosis, and liver fibrosis as revealed by H&E, Oil Red O, F4/80, TUNEL, Sirius red and Masson staining, respectively (Fig. 5k and l). Here, IGF2BP2 is linked to Hepatic steatosis.