INS and type 1 diabetes mellitus: Similarly, many drugs may have potential clinical therapeutic value, such as mogroside V (MV), which promotes the ability of bone marrow mesenchymal stem cells (BMSCs) to differentiate into osteoblasts in diabetic mice (137), Icariin (ICA), which induces osteogenic-angiogenic coupling in a rat model of type 1 diabetic bone defects (138), and the combination of insulin (I) and naringin (NAR), which prevented osteoclast proliferation in type 1 diabetic rats (139).