In this study, through a combined analysis of 8 T1D and T2D RNAseq datasets, we proved that the COL1A2/VCAN/SULF1 gene panel is positively related to the activation status of PSCs, and COL1A2hi/VCANhi/SULF1hi PSCs are found to be the shared features of multiple T2D samples rather than T1D samples. This evidence concerns the gene VCAN and type 1 diabetes mellitus.