We also examined the correlation between the 3-gene panel (COL1A2/VCAN/SULF1) and this 7-gene panel in PSCs, and found a significantly high correlation relationship, as shown in Figure 9B, suggesting this 3-gene panel could be used as an indication of the activation status of PSCs, and these 3 genes might regulate T2D progression through regulating the activation status of PSCs. The gene discussed is VCAN; the disease is type 2 diabetes mellitus.