Cells in c0 cluster derived from T2D samples have the highest expression level of 743 up-regulated genes compared to other samples (Figure 6D); regarding GSE195986_c3 mesenchymal cells, 3 clusters were generated (Figure 6E, metafile in Supplementary Table 9) in which c2 (PSCs, 1907 cells) has the highest expression of PDGFRB gene (Figure 6F), as well as 743 up-regulated genes from GSE164416 (Figure 6G). This evidence concerns the gene PDGFRB and type 2 diabetes mellitus.