Cells in c2 cluster derived from T2D samples have the highest expression level of 743 up-regulated genes compared to other samples (Figure 6H); regarding GSE81608_c6 mesenchymal cells, 3 clusters were generated (Figure 6I, metafile in Supplementary Table 10) in which c0 (PSCs, 72 cells) has the highest expression of PDGFRB gene (Figure 6J), as well as 743 up-regulated genes from GSE164416 (Figure 6K). The gene discussed is PDGFRB; the disease is type 2 diabetes mellitus.