VCAN and type 1 diabetes mellitus: To verify whether COL1A2hi/VCANhi/SULF1hi PSCs are specifically enriched in T2D samples rather than T1D samples, we retrieved two scRNAseq datasets including GSE86469 (16) (containing 258 T2D and 380 ND pancreatic islet cells) and GSE148073 (17) (containing 5 T1D pancreatic islet samples and 6 ND pancreatic islet samples), and examined the expression status of COL1A2, VCAN, and SULF1 in PSCs.